Prior to the arrival of European navigators in the late 1700s, the Victoria area was home to several communities of Coast Salish peoples, including the Songhees. 

The Spanish and British took up the exploration of the northwest coast, beginning with the visits of Juan Pérez in 1774, and of James Cook in 1778. Although the Victoria area of the Strait of Juan de Fuca was not explored until 1790, Spanish sailors visited Esquimalt Harbour (just west of Victoria proper) in 1790, 1791, and 1792.

In 1841 James Douglas was charged with the duty of setting up a trading post on the southern tip of Vancouver Island, upon the recommendation by George Simpson a new more northerly post be built in case Fort Vancouver fell into American hands (see Oregon boundary dispute). Douglas founded Fort Victoria on the site of present-day Victoria in anticipation of the outcome of the Oregon Treaty in 1846, extending the British North America/United States border along the 49th parallel from the Rockies to the Strait of Georgia.

When news of the discovery of gold on the British Columbia mainland reached San Francisco in 1858, Victoria became the port, supply base, and outfitting centre for miners on their way to the Fraser Canyon gold fields, mushrooming from a population of 300 to over 5000 within a few days. Victoria was incorporated as a city in 1862. In 1865, the North Pacific home of the Royal Navy was established in Esquimalt and today is Canada's Pacific coast naval base. In 1866 when the island was politically united with the mainland, Victoria was designated the capital of the new united colony instead of New Westminster – an unpopular move on the Mainland – and became the provincial capital when British Columbia joined the Canadian Confederation in 1871.

Fun Fact: In the latter half of the 19th century, the Port of Victoria became one of North America's largest importers of opium, serving the opium trade from Hong Kong and distribution into North America. Opium trade was legal and unregulated until 1865, when the legislature issued licences and levied duties on its import and sale. The opium trade was banned in 1908.